New paper published in FASEBJ on the role of Scleraxis in tendon enthesis maturation

Check out our most recent paper, Scleraxis is required for the development of a functional tendon enthesis (Killian Thomopoulos FASEBJ 2015), which was just published in the FASEB Journal. This work identified Scleraxis as an important contributor to enthesis maturation by showing that loss of Scleraxis leads to impaired biomechanical function of the tendon-to-bone attachment and also leads to altered cell shape, collagen organization, fibrocartilage density, and molecular response at the attachment. These changes were not solely caused by reduced muscle activity, but likely due to the role of Scleraxis on periosteal and fibrocartilage tissues during rapid growth. These findings emphasize the importance of individual tissue development, cellular interaction, and regulation of molecular factors in the assembly and homeostasis of musculoskeletal organs, such as the enthesis.