The Killian Lab recently received funding from the National Institutes of Health (Eunice Kennedy Shriver National Institute of Child Health and Human Development) to develop in vivo optogenetics tools for the control of skeletal muscle contraction. We will use these tools to identify the role that increased muscle loading plays on enthesis maturation during postnatal … Continue reading R03 awarded to develop tools for controlling rotator cuff muscle activation using light
Ryan Locke (1st year PhD student in Dr. Killian's lab) and Professor Killian co-authored a review, published in ACS Biomaterials Science and Engineering, on the multiscale, morphological, and mechanical characteristics of the fibrocartilage attachment. This review discusses historical and recent clinical approaches to treating enthesis injury and explores new technological advancements in tissue-engineered biomaterials that have shown promise … Continue reading New review published in ACS Biomaterials Science and Engineering
The Killian Lab recently received a COBRE Osteoarthritis Pilot Grant from the NIH Center of Biomedical Research Excellence (NIH P30-GM103333) and Delaware Rehabilitation Institute to study the role of fibroblast growth factor 18 (FGF18) and muscle loading on the maturation of orthopaedic joints and attachments. Congratulations!
Check out our most recent paper, Scleraxis is required for the development of a functional tendon enthesis (Killian Thomopoulos FASEBJ 2015), which was just published in the FASEB Journal. This work identified Scleraxis as an important contributor to enthesis maturation by showing that loss of Scleraxis leads to impaired biomechanical function of the tendon-to-bone attachment and also leads to … Continue reading New paper published in FASEBJ on the role of Scleraxis in tendon enthesis maturation