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Laboratory of Integrative Musculoskeletal Biomechanics and Rehabilitation

Killianlab

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  • Home
  • Research
  • People
  • Contact
  • Publications
  • News
  • Lab Policies and Tips

Publications

Google Scholar

2018

  • E Ganji, ML Killian. Tendon Healing in the Context of Complex Fractures. Clinical Reviews in Bone and Mineral Metabolism 16 (4), 131-141, 2018.
  • ML Killian, RC Locke, MG James, PR Atkins, AE Anderson, JC Clohisy. Novel model for the induction of postnatal murine hip deformity, Journal of Orthopaedic Research,  2018. JOR Early Career Award
  • EA Lemmon, RC Locke, AK Szostek, E Ganji, ML Killian. Partial-Width Injuries of the Rat Rotator Cuff Heal with Fibrosis. Connective tissue research, 59(5), 437-446, 2018. Selected for Cover Art.

2017

  • SA Shah, I Kormpakis, L Cavinatto, ML Killian, S Thomopoulos, LM Galatz. Rotator cuff muscle degeneration and tear severity related to myogenic, adipogenic, and atrophy genes in human muscle. Journal of Orthopaedic Research, 35 (12), 2808-2814, 3, 2017.
  • RC Locke, JM Peloquin, EA Lemmon, A Szostek, DM Elliott, ML Killian. Strain Distribution of Intact Rat Rotator Cuff Tendon-to-Bone Attachments and Attachments With Defects. Journal of biomechanical engineering, 139 (11), 111007 4, 2017.
  • A Gingery, ML Killian. Special Focus Issue on Strategic Directions in Musculoskeletal Tissue Engineering, Tissue Engineering Part A, 23 (17-18), 873-873, 2017. Guest editorial role.
  • ML Killian, A Gingery, Special Focus Issue on Strategic Directions in Musculoskeletal Tissue Engineering, Tissue Engineering Part A, 23 (15-16), 717-718, 2017. Guest editorial role.
  • CA Ford, NC Nowlan, S Thomopoulos, ML Killian. Effects of imbalanced muscle loading on hip joint development and maturation. Journal of Orthopaedic Research, 35 (5), 1128-1136, 2017.
  • JA McKenzie, E Buettmann, AC Abraham, MJ Gardner, MJ Silva, & ML Killian. Loss of scleraxis in mice leads to geometric and structural changes in cortical bone, as well as asymmetry in fracture healing. The FASEB Journal, 31 (3), 882-892, 2017.

2016

  • RC Locke, AC Abraham, ML Killian. Orthopaedic interface repair strategies based on native structural and mechanical features of the multiscale enthesis. ACS Biomaterials Science & Engineering.
  • ML Killian & S Thomopoulos. Scleraxis is required for the development of a functional tendon enthesis. The FASEB Journal, 30 (1), 301-311, 2016.

2015

  • ML Killian, LM Cavinatto, SR Ward, N Havlioglu, S Thomopoulos, … Chronic degeneration leads to poor healing of repaired massive rotator cuff tears in rats. The American journal of sports medicine 43 (10), 2401-2410. 2015.
  • EJ Sato, ML Killian, AJ Choi, E Lin, AD Choo, AE Rodriguez-Soto, CT Lim, … Architectural and biochemical adaptations in skeletal muscle and bone following rotator cuff injury in a rat model. J Bone Joint Surg Am 97 (7), 565-573, 2015.

2014

  • ML Killian, RC Haut, & TLH Donahue. Acute cell viability and nitric oxide release in lateral menisci following closed-joint knee injury in a lapine model of post-traumatic osteoarthritis. BMC musculoskeletal disorders 15 (1), 297, 2014.
  • EJ Sato, ML Killian, AJ Choi, E Lin, MC Esparza, LM Galatz, … Skeletal muscle fibrosis and stiffness increase after rotator cuff tendon injury and neuromuscular compromise in a rat model. Journal of Orthopaedic Research 32 (9), 1111-1116, 2014.
  • E Zelzer, E Blitz, ML Killian, & S Thomopoulos. Tendon‐to‐bone attachment: From development to maturity. Birth Defects Research Part C: Embryo Today: Reviews 102 (1), 101-112, 2014.
  • ML Killian, L Cavinatto, SA Shah, EJ Sato, SR Ward, N Havlioglu, … The effects of chronic unloading and gap formation on tendon‐to‐bone healing in a rat model of massive rotator cuff tears. Journal of Orthopaedic Research 32 (3), 439-447, 2014.

2013

  • ML Killian, CT Lim, S Thomopoulos, N Charlton, HM Kim, & LM Galatz. The effect of unloading on gene expression of healthy and injured rotator cuffs. Journal of Orthopaedic Research 31 (8), 1240-1248, 2013.

2012

  • ML Killian, L Cavinatto, LM Galatz, &. S Thomopoulos. Recent advances in shoulder research. Arthritis research & therapy 14 (3), 1, 2012.
  • ML Killian, L Cavinatto, LM Galatz, & S Thomopoulos. The role of mechanobiology in tendon healing. Journal of Shoulder and Elbow Surgery 21 (2), 228, 2012.

2011

  • ML Killian, B Zielinska, T Gupta, & TLH Donahue. In vitro inhibition of compression-induced catabolic gene expression in meniscal explants following treatment with IL-1 receptor antagonist. Journal of Orthopaedic Science 16 (2), 212-220, 2011.

2010

  • ML Killian, DI Isaac, RC Haut, LM Déjardin, D Leetun, & TL Haut Donahue. Traumatic anterior cruciate ligament tear and its implications on meniscal degradation: a preliminary novel lapine osteoarthritis model. Journal of Surgical Research 164 (2), 234-241, 2010.
  • ML Killian, NM Lepinski, RC Haut, & TL Haut Donahue. Regional and Zonal Histo‐Morphological Characteristics of the Lapine Menisci. The Anatomical Record 293 (12), 1991-2000, 2010.

2009

  • B Zielinska, M Killian, M Kadmiel, M Nelsen, & TL Haut Donahue. Meniscal tissue explants response depends on level of dynamic compressive strain. Osteoarthritis and Cartilage 17 (6), 754-760, 2009.

Research

Our research focuses on understanding the development and maturation of the tendon-bone enthesis, as well as understanding the mechanical and molecular mechanism(s) that regulate tissue remodeling during post-natal growth and healing following injury.

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People

We are an interdisciplinary team of undergraduates, graduate students, and technical staff engaged in research to understand musculoskeletal development and healing.

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Contact

Interested in opportunities in the Killianlab? Want to chat about potential collaboration? Contact us!

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Lab NEWS

  • Killian Lab at the ORS February 11, 2019
  • New paper in Clinical Reviews in Bone and Mineral Metabolism: Tendon healing in the context of complex fractures January 1, 2019
  • JOR Early Career Award December 5, 2018
  • R03 awarded to develop tools for controlling rotator cuff muscle activation using light December 4, 2018
  • Ryan’s Recap of ORS 2018 April 9, 2018
  • Art in Science March 23, 2018
  • Recent publications from LIMBR March 16, 2018

Find us on Instagram

Nice job @p.rayeh at your first #ors2019 !! Photo credit @p.rayeh
Way to go @ryanclocke on your talk at #ors2019
Bill and Jordan are quickly becoming gurus at microct reconstruction and 3d visualization!
Need oxygen? Come visit Dr Killian's office! #plants #cleanair
Cool histology by @through_wolfs_eyes (from a neonatal shoulder) made it on @udelaware UDaily!
Can we get a round of applause for our @udbme seniors? They crushed it today at their final presentations for senior design and took home so many awards!! Woohoo!! Way to go! @theotherellend_ @andrew_rey @akmcgough @mleibowitz97 @vjones918

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5 Innovation Way, Suite 200
Newark, DE 19716

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